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In the realm of chemotherapy, the concomitant use of doxorubicin and sodium selenite has shown a synergistic inhibition of prostate cancer cell proliferation, surpassing the effects of doxorubicin in isolation (111)

To avoid metHb accumulation, reducing pathways mediated by cytochrome b5 or flavin coupled with NADH- or NADPH-dependent metHb reductases (MHbR), respectively, keep the level of metHb in erythrocytes at less than 1% of the total Hb under normal conditions (48)

Males typically experience accelerated frontal recession and vertex thinning, whilst females may develop diffuse thinning patterns with preserved frontal hairlines