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After binding to the IL-1 type I receptor, IL-1 could mediate the activation of the HPA axis in the rodent model of depression (79), which provides evidence for IL-1s role in activating the HPA axis

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5 Bottom line, when compared to the established antiviral treatment, acyclovir, lysine is a safe natural compound without reported adverse side effects and is a promising alternative treatment option for patients with HSV