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In a separate six-year trial of 320 participants with Type 2 diabetes treated with pioglitazone, metformin a diabetes drug used for blood glucose control and exenatide, about 75% of participants achieved an A1c of less than 6.5, while 70% of the subjects receiving standard therapy of metformin, sulfonylurea and insulin failed to achieve an A1c of less than 6.5 after 6 years

Romera et al, 2019

The role of HPA axis and allopregnanolone on the neurobiology of major depressive disorders and PTSD