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10.1016/j.juro.2013.08.110 J Urol

some tumors rely on it for survival under high oxidative pressure, while deficiencies in healthy cells might promote tumor initiation through DNA damage

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Using a long-term HFD-fed mouse model of NAFLD, we demonstrated in this study that NAFLD development occurs concomitantly with dysregulated hepatic glutathione homeostasis characterized by decreased GSH and increased GSSG, and increased TNF protein levels in both the circulation and the liver