& Pairault, J
Companies are testing oral semaglutide for weight loss and introducing small-molecule GLP-1 receptor agonists like orforglipron, which may offer similar efficacy without injections
According to the Zepbound prescribing information, tirzepatide commonly causes nausea (24-29%), diarrhea (18-24%), vomiting (8-11%), constipation (16-17%), and abdominal pain (10-15%), with rates increasing at higher doses
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Anxiety surrounding missing meals and when a person will eat next can have negative physical effects, including increased blood pressure, reduced focus, weight gain and disrupted sleep