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The Current GLP-1 Landscape GLP-1 (glucagon-like peptide-1) receptor agonists were initially developed to help manage type 2 diabetes by improving insulin sensitivity and reducing blood glucose levels

Native GLP-1 has been infused by the subcutaneous route (4.8 pmol/kg/min) using a portable insulin pump in a non-randomized study of subjects with type 2 diabetes over the age of 40 (mean age 55) with mean initial HbA1c of about 9%, and mean fasting glucose ~14 mM

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Mazdutide is a synthetic peptide that acts as a GCGR+GLP-1R dual agonist, currently being developed in China in collaboration with Sinopharm for the treatment of type 2 diabetes and obesity.

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