This dramatically extends usable lifespan compared to liquid formulations, which degrade within weeks of production
Notably, inappropriately elevated glucagon levels are a characteristic feature of APD treatment in humans and rodents 16,19,20,21
Funding This work was supported by the National Natural Science Foundation of China (32102293), the National Key Laboratory of Green Pesticide, Guizhou University (GPLKF202506), the Carbon Peak Carbon Neutral Science and Technology Innovation Special Fund of Jiangsu Province (BE2022424), the Jiangsu Agricultural Science and Technology Innovation Fund (CX(24)2008 and CX(22)1001), the Earmarked Fund for CARS (Rice, CARS-01-26), the Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX23_3578 and SJCX24_2276), the College Students Innovative Entrepreneurial Training Plan Program (202411117194Y), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Melanosis coli was first described by Cruveilhier in 1829 as a condition affecting the colon from the cecum to the dentate line, with pigmentation ranging from a barely discernible brown to jet black.1 Its presence is a reliable indicator of anthracene laxative abuse (i.e., cascara, aloe, senna and rhubarb).2 , 3 After the ingestion of such laxatives, anthracene is converted from its glucuronated form to its active form by cecal bacteria, resulting in damage to the colonic epithelium
Pan et al., 2012)
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