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Conditions associated with altered glutamate homeostasis include drug addiction, chronic pain, depression, schizophrenia, and neurodegenerative disorders [107], suggesting potential applications for NAC as adjuvant therapy in these disorders

Science 363 , 13451349 (2019)

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Less Common and Long-Term Considerations While the common side effects are usually fleeting, there are a few specific scenarios that require a more nuanced understanding of how glutathione interacts with the body over time

Research has demonstrated that several factors, including concentration, type of preparation, kava pyrone content, and kava variety used may affect pharmacologic activity