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doi: 10.1016/0306-4522(92)90524-6

Safety of supplemental choline: The tolerable recommended upper intake level for choline is set at 3,500 mg/day for adults

Due to challenges in medicinal chemistry, one antagonist (VENT-03, targeting cGAS) has been advanced into phase I clinical trials, which aims to evaluate the safety of VENT-03 in healthy volunteers, and subsequent trial plans will target the treatment of autoimmune diseases (118)

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