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Here we report that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supports tendon gliding and strong adhesion (larger than 1,000 J m 2 ) to tendon on opposite surfaces of the hydrogel, as we show with porcine and human tendon preparations during cyclic-friction loadings

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Side effects are minimal and may include mild fatigue or redness at the injection site

Am J Phys Regul Integr Comp Phys

Rarely: 1 to 10 treated patients in 10,000