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Gut Inflammation and Imbalances A condition known as enteropathy (intestinal inflammation) has been associated with most gastrointestinal diseases, including intestinal infections, celiac disease, chronic diarrhea, irritable bowel syndrome, Crohns disease, and others

Kennedy has worked to reverse those curbs.

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The review covered GLP-1s roles in controlling islet function, appetite, inflammation, and cardiovascular pathophysiology, and made a critical mechanistic distinction: native GLP-1 acts primarily via paracrine and neural mechanisms (given its 12 minute plasma half-life), whereas GLP-1RA drugs with extended half-lives act systemically on GLP-1R populations inaccessible to the native peptide