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Limited brain penetration of agonists: Studies using fluorescently labelled GLP-1 receptor agonists like semaglutide and liraglutide have shown very limited penetration into most brain regions beyond the circumventricular organs areas where the bloodbrain barrier is less effective and allows the brain to sample blood contents

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doi: 10.1016/j.jmb.2020.05.023 44 ChenYLiYWuL

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