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SAM-e has been approved and marketed as a treatment for psychiatric disorders in Europe for over 25 years, but, in the US, it is sold as an over-the-counter supplement [ R ]

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2.3 Pathological basis of metabolic dysregulation 2.3.1 BCKDH activity reduction in obesity and insulin resistance Substantial epidemiological evidence indicates that patients with obesity and insulin resistance exhibit significantly elevated plasma BCAA levels, closely associated with reduced tissue BCKDH activity (36)

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