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This landmark study remains one of the strongest demonstrations of a neuropeptide's sleep-promoting activity in preclinical models Eur J Neurosci (2007) -- further characterization of cortistatin's sleep neurobiology, confirming the initial findings Anti-inflammatory studies -- cortistatin has demonstrated potent anti-inflammatory effects in multiple preclinical models (IBD: PNAS 2006, sepsis: J Leukoc Biol 2006, arthritis, atherosclerosis)

These physiological effects on Glp1r + Ghsr + neurons may modulate the anorectic or orexigenic signals that they convey to the brain

These findings identify adipose tissue as an important therapeutic target of triple incretin agonism and establish tissue quality restorationrather than mere mass reductionas a new therapeutic paradigm for obesity and related metabolic disorders

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