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Lipids Lipids are another source of energy for the CNS, and in the brain they are supplied by two processes: endogenous synthesis by glial cells and the transfer of free cholesterol across the BBB ( In the brain there is a relatively low rate of oxidation of fatty acids due to the production of ROS- byproduct of cellular metabolism during mitochondrial OXPHOS that induces cell death in newly differentiated cortical neurons at higher concentrations ( in utero vs