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Structure GSTs consist of the following three superfamilies: cytoplasmic (cGSTs), mitochondrial (GSTs), and microsomal (membrane-associated proteins in eicosanoid and glutathione metabolism [MAPEG])

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Pathogenic mutation of the tartrate-resistant acid phosphatase ACP5 leads to a strong predisposition to autoimmune diseases, associated with the accumulation of phosphorylated osteopontin, involved in immune regulation and in bone resorption (138)