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With the presence of three proline residues (P195 ECL1 , P197 ECL1 and P199 ECL1 ), the ECL1 of GIPR presents a notable conformational adaptability in recognition of different agonists, a phenomenon that was not seen with that of GLP-1R and GCGR as their binding pockets exhibit less flexibility when recognizing the peptides through a combination of common segment that contributes to conserved interactions and distinct sequences that govern receptor selectivity

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While further interventional research is necessary, the current study adds to the growing evidence on the neurobehavioral benefits of GLP-1 RAs and supports their dual utility in managing both metabolic and psychiatric comorbidities

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