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Alterations in gut microbiota composition can affect TPH1 activity and thereby influence 5-HT levels

In addition, stabilized peptide systems are essential for ensuring reproducible research outcomes

PubMed 31611038 Wikipedia

In this phase II trial involving 50 men with metastatic castration-resistant prostate cancer (mCRPC), the administration of docetaxel combined with oral curcumin (6 g/day for 7 days every 3 weeks) demonstrated no significant differences in progression-free survival (PFS), PSA response, overall survival, or quality of life (QoL) when compared with placebo, despite high compliance and confirmed curcumin absorption

Heidari-Khoei H, Esfandiari F, Moini A, Yari S, Saber M, Ghaffari Novin M, Piryaei A, Baharvand H (2022) Derivation of hormone-responsive human endometrial organoids and stromal cells from cryopreserved biopsies