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Acquisition, analysis, or interpretation of data: S.Y., E.S.Y., J.I.K., J.W.S

PlexusDx's Precision Peptide Genetic Test identifies individual variations in four key peptide-pathway genesGIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313that influence GLP-1 receptor sensitivity and satiety signaling

Additional pharmacological characterization by our group corroborates its hMC3R potency (EC 50 = 4.2 nM, E max = 91%) and demonstrates enhanced hMC4R potency (EC 50 = 0.048 nM, E max = 100%) (25)

This imbalance promotes increased intestinal and blood-brain barrier (BBB) permeability, allowing inflammatory molecules from the intestine to reach the brain and vice versa, and can cause systemic and neuroinflammation

Coffee, even black coffee, reduces absorption and should be consumed at least 30 minutes after taking levothyroxine