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(2020) 36:e3213
El-Hamamsy I, Stevens LM, Carrier M, et al
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Notably, however, we found that the co-therapy of acyl-GLP-1 (10 nmol kg 1 ) and the acylated GIPR antagonist (1,500 nmol kg 1 ) equally decreased body weight in DIO WT and Per-Gipr KO mice, with superiority of the co-therapy relative to treatment with acyl-GLP-1 alone (Fig
Pair this with elevated cortisol, insulin resistance, and chronic inflammation, and youve got a metabolic storm working against you
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