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Back Finan, B, Yang, B, Ottaway, N, et al (2015) 'A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents', Nature Medicine , 21, 27-26

Cheng, Z., Zou, C

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Vitamins A and D also improve gut barrier integrity through modulating TJ protein expression, with reduced vitamin A consumption in rats resulting in impaired TJ barriers most likely a consequence of the decreased expression of ZO-1 and occludin also reported

The standard clinical protocol involves gradual dose escalation designed to minimize gastrointestinal side effects while building toward therapeutic levels