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This cycling approach prevents receptor desensitization and maintains effectiveness across multiple cycles

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1.11 Immune-checkpoint inhibitors and autoimmune thyroiditis Through the inhibition of immune regulatory pathways that impair T-cell antitumor responses, immune checkpoint inhibitors (ICIs) have made significant progress in the treatment of cancer

These include viral envelope glycoproteins and bacterial toxins, as well as cellular factors that promote tumorigenesis 336