Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial
Though, some recommendations are common among all patients
Side effect tolerability edge: semaglutide (slight) Both drugs have similar side effect profiles overall
If you are using lyophilized (freeze-dried) semaglutide powder, correct reconstitution is important to suit right dosing and to keep the peptide stable
FDA Mounjaro label 2026 Approvals breadth edge: semaglutide Semaglutide currently holds more FDA indications including proven cardiovascular benefit, adolescent use, an oral formulation, and the newly approved MASH indication giving it an advantage in breadth of clinical application