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Description

The Phase 2 trial ran for 48 weeks with continuous dosing

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Active capase-1 converts pro-IL-1 and pro-IL-18 into their mature forms causing pyroptotic cell death [5, 10, 11]

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The apparent spread of pigment into the cuticle, nail fold and surrounding areas of a nail (the periungual area) is a very worrisome sign even when its detected only upon magnification

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W.van der MeiH

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