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Improves insulin sensitivity: A 2025 meta-analysis of 17 randomized controlled trials involving nearly 6,000 women found that HRT significantly reduced insulin resistance (HOMA-IR) in healthy postmenopausal women [8]

The energy improvement is worth noting specifically

Deficiency can result in low energy, poor concentration, and mood imbalances

Abstract Cyclophosphamide (CP), a widely used chemotherapeutic agent, often induces chemotherapyinduced peripheral neuropathy (CIPN)

Lithium interferes with the HPA axis by enhancing the release of corticotropin-releasing hormone (CRH), vasopressin (AVP), adrenocorticotropic hormone (ACTH), cortisol, and glucocorticoid receptor (GR) messenger RNA