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Metformin is not FDA-approved for weight loss.

Kido J, Matsumoto S, Hberle J, Nakajima Y, Wada Y, Mochizuki N, Murayama K, Lee T, Mochizuki H, Watanabe Y, Horikawa R, Kasahara M, Nakamura K (2021a) Long-term outcome of urea cycle disorders: report from a nationwide study in Japan

Oral semaglutide was superior to placebo, sitagliptin, and liraglutide and similar to empagliflozin, with losses up to 4.44 kg compared with 0.53.6 kg for active-comparator arms and 0.41.4 kg compared with placebo [35,36,37,38,39,40]

Metformin (Fortamet, Glumetza) and semaglutide (Ozempic, Rybelsus ) are medicines that treat type 2 diabetes

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