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This becomes more relevant with extended use, typically after several months

Neurotherapeutics (2010) 7:2419.10.1016/j.nurt.2010.05.004 20 FryeREDelatorreRTaylorHBSlatteryJMelnykSChowdhuryNet alMetabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study

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However, these studies are generally small, not all of them are randomized controlled trials, and many were published in Russian journals that are less accessible to the broader scientific community for independent verification