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Meanwhile, Lp(a) is associated with various pro-thrombotic mechanisms, such as platelet aggregation via thrombin-mediated activation of PAR1 and oxidised phospholipid (OxPL)-mediated activation of CD36 [40], and Lp(a)-induced cytokines promote inflammation, and macrophages are induced by apo(a) to release interleukin-8, monocyte chemotactic proteins, and tumour necrosis factor-alpha (TNF-) [41] (Fig