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Eli Lillys own development materials describe the molecule as built on a GIP backbone with non-natural amino acid substitutions (including Aib residues) that improve protease resistance, plus C-terminal amidation for stability

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By developing the anonymous receptor identification by reverse-G-protein pull-down (ARIG) method, we identify orphan OR Or5v1/Olfr110 as an oxylipin 12(S)-hydroxyeicosapentaenoic acid (12(S)-HEPE) receptor