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Studies on dermal fibroblasts have documented up to 70% increases in collagen I production at optimal concentrations of 1 nanomolar

There are no jitters, no appetite suppression through hormonal signaling, and no dependency concerns that come with stimulant-based approaches

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But even in those, the effect sizes are relatively small, and in the clinic the results are often more disappointing than the trials would suggest. Dr Whittle said due to the nature of fibromyalgia, there was unlikely to be a magic bullet or single receptor pharmacotherapeutic intervention that was broadly or substantially successful in most people with fibromyalgia

You can see a table detailing this below and at 1:21 in my video Do Vitamin B12 Supplements Cause Acne