Adequate protein intake and nutritional supplementation can mitigate this risk
Participants treated with semaglutide experienced significantly diminished cravings for sweet, savory, and dairy-rich foods compared to those receiving placebo after 20 weeks of therapy and during the active phase of weight loss (Friedrichsen et al., 2021)
That model-specific selectivity does not guarantee absent cortisol, prolactin, appetite or other effects in humans or with unstudied routes
Eder K, Felgner J, Becker K, Kluge H
A 2021 study published in Lancet Diabetes & Endocrinology examined body composition changes with semaglutide and found that approximately 70% of weight lost was fat mass, with notable reductions in visceral adipose tissue volume