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Although the information in this chapter is provided as background to this report, the committee acknowledges the importance of developing good animal models and identifying biomarkers of the disease progression and outcomes, and therefore recommendations are made for improving these areas of research

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It is also reported that L-carnitine supplementation can improve the glycemic status and related indices by changing the expression of genes related to glycolytic and gluconeogenic enzymes, modulating the activity of the pyruvate dehydrogenase enzyme complex, and changing the expression of genes involved in insulin metabolism (94, 95)

Do I need a Therapeutic Use Exemption (TUE) to use GLP-1s