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Medical Management of Kidney Stones: AUA Guideline

The risk of lean mass loss during rapid weight reduction on tirzepatide is a particular concern for autoimmune patients who may already have muscle wasting from disease activity, corticosteroid use, or reduced physical activity during flares

However, further research is needed to confirm this potential association

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GLP-1 stimulates insulin secretion when blood glucose levels are elevated, suppresses glucagon release (which normally raises blood sugar), slows gastric emptying, and reduces appetite through effects on the brain's satiety centres