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If persulfides naturally play a role in limiting LPO, the expression levels of enzymes involved in persulfide generation and turnover can be expected to influence lipid oxidation levels and ferroptosis sensitivity

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Theyre also testing it in combination with tirzepatide in a separate Phase 2 study for people with elevated BMIs and type 2 diabetes, to see if targeting multiple hormone pathways could lead to even better results

255,256,257 Liver-specific deletion of Lgr4 significantly restrains liver regeneration