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Nutritional intervention is expected to become the third major treatment modality alongside physical therapy and drug therapy, bringing significant benefits to patients with mild to moderate OA and effectively reducing the proportion of severe OA patients, which allow more people to avoid the adverse effects of repeated drug treatment and the potential risks of surgery and prosthesis replacement

Yet this new work shows that under the extreme energetic load of hypertrophic cardiomyopathy (HCM), CK becomes the weak link : hypercontractility and mitochondrial oxidative stress inactivate CK, breaking the hearts energy relay

doi: 10.1155/2022/3846217 176 YuRZhouYShiSWangXHuangSRenY

Reactions were initiated by the addition of 2 mM NADH

Passani MB, Panula P, Lin JS