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Both medications, similar to all other GLP-1 weight loss drugs, share similar common side effects, including: Nausea Diarrhea Vomiting Constipation Some early data indicate that retatrutide may have slightly higher rates of certain side effects compared with semaglutide at higher doses because it mimics 3 different hormones and is more potent
MC4R, on the other hand, plays an important role in regulating appetite and sexual function, which explains the additional effects observed in people using MT2
Whether it's chasing KOMs/QOMs, optimizing that all-important power-to-weight ratio, or just feeling lighter on the climbs, body composition is often part of the cycling conversation
This combination is considered highly experimental and should only be approached within the context of formal, controlled research due to the risk of unknown interactions