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The main side effects are nausea, vomiting, diarrhea, and headaches, Paulvin says

[13] [14] under the brand name Wegovy for weight management

But there are growing questions about how it might affect fertility and reproductive hormones

People least likely to quit using GLP-1 drugs are those using them to manage diabetes and those with higher incomes

Best Weight Loss Medication 2026: Complete GLP-1 Comparison Guide Best Weight Loss Medication 2026: Complete GLP-1 Comparison Guide Tirzepatide (Zepbound, Mounjaro) is the most effective weight loss medication in 2026, producing 15-22% average body weight loss in clinical trials, followed closely by semaglutide (Wegovy, Ozempic) with 10-15% average weight loss, with both significantly outperforming all other FDA-approved weight loss medications