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If you or any of your family members have a history of Medullary Thyroid Carcinoma (MTC) or Endocrine Neoplasia Syndrome type 2 (MEN2), it is advisable not to take GLP-1.

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This hypothesis is supported by preclinical studies showing that early life traumatic stress is associated with chronic anxiety, spatial memory deficits and reduced expression of GABA A R subunits in the adult rat brains (351)