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Release the plunger to allow pressure to equalize naturally

The STEP trials demonstrated that semaglutide reduces body weight by 1522% over 68 weeks compared to placebo when combined with lifestyle changes

The phase 2a trials of NNC0090-2746 in people with diabetes and obesity also showed significant improvements in HbA1c over placebo with a placebo-subtracted reduction of 0.96% over 12 weeks treatment, as well as placebo-subtracted reductions in weight of up to 1.8% [56]

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This drug has been demonstrated to exhibit several distinct modes of actions, one of them being the irreversible modulation of KEAP1 active cysteine residues (Table 1)