Appendicitis also did not increase risk of CRC: Sakaue S (OR:1.018, 95%CI:0.950-1.091, P=0.609)
That could give Novo Nordisk an edge in its increasingly competitive tussle in the GLP-1 market with Eli Lilly, which recently won FDA approval for its oral GLP-1 drug, Foundayo (orforglipron), as an obesity therapy to rival Novo Nordisk's Wegovy pill version of semaglutide for weight loss
Zepbound (tirzepatide) a once-weekly injection specifically approved for chronic weight management in certain countries
While GI side effects have been suggested to be involved in mediating the weight-loss effect of GLP-1RAs, analysis of large clinical trial data sets with liraglutide and semaglutide has shown that, while GI side effects may lead to more initial weight loss, they are not the mechanism of weight loss as many patients have weight loss and no side effects (182, 183)
Veterinary Applications and Translational Insights Interestingly, both peptides have demonstrated therapeutic potential in veterinary applications, and clinical experience in animal medicine may provide valuable insights into safety and efficacy profiles
