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The parallel Ras-Raf-MEK-ERK1/2 arm (ERK Thr-202/Tyr-204 phosphorylation +1.2-1.4 at 15-30 minutes) drives myoblast proliferation (BrdU +28-34%) via cyclin D1 upregulation and Rb phosphorylation

Notably, ozone moderates inflammation by curtailing pro-inflammatory cytokines, such as interleukin 6 (IL-6), and simultaneously promotes anabolic activity, as evident by elevated insulin-like growth factor 1 (IGF-1) levels [33, 34]

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