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It is predominantly metabolised by CYP3A4 in the liver into the N-monodesmethyl (M2) metabolite, which exhibits anti-tubercular activity, albeit with approximately five times less potency than the parent drug

[DOI] [PubMed] [Google Scholar] 66.Gormley GJ, Stoner E, Bruskewitz RC, Imperato-McGinley J, Walsh PC, McConnell JD, Andriole GL, Geller J, Bracken BR, Tenover JS, et al

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