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Normally, FOXO4 binds to p53 in senescent cells (cells that no longer divide but are still active), stopping p53 from triggering apoptosis, or programmed cell death
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[162] reported that Infliximab treatment in doxorubicin-administered rats remarkably reverses damaging effects such as AD-like brain injury, upregulated amyloid burden, increased neuroinflammation and apoptosis, and multifocal histological injury in the cerebral cortex with widespread vacuolations (Fig