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Patients with autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and T1D, have been shown to have lower levels of CTLA4 mRNA ( Another critical regulator of various immunological processes associated with multiple autoimmune disorders is CD226, a member of the immunoglobulin superfamily ( Cd226 conditional knockout model, female NOD mice also displayed decreased insulitis and diabetes incidence, supporting the notion that CD226 is involved in Treg stability ( 3.2 Genetic influence on environmental response: the IFIH1 , TYK2 , and FUT2 genes Among the genes linking genetics to environmental triggers, Interferon-Induced with Helicase Domain 1 ( IFIH1 ) stands out for its direct role in the immune response to viruses, a major suspected trigger for T1D