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Using animal models of neurological injury, studies have demonstrated that T4 can target multiple neural cells (including neurons, oligodendrocytes and microglia) and can also provide neuroprotection, immunosuppression, and neurorestoration, including remyelination, synaptogenesis, and axon growth (Zhang et al., 2016a, Zhang et al., 2016b, Chopp and Zhang, 2015, Santra et al., 2012, Santra et al., 2016, Wang et al., 2015, Wang et al., 2012, Cheng et al., 2014)

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IGFBP3 has been linked to hypertension, obesity and cardiovascular disease[17]