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Unlike earlier broad-spectrum senolytics that can harm healthy tissue, FOXO4-DRI targets a molecular interaction unique to senescent cells

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Previously, selective antitumor activity was observed in H1299 lung cancer cells over WI38 normal lung fibroblasts cells, and the principle and mechanism of GSH-responsive AP probe-net had been briefly confirmed in vitro [11]

The group said it is important for the agency to develop guidance that aligns with international regulators to enable a more streamlined regulatory pathway

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