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Brtsch SH, Wang CC, Li L, Stender H, Neziroglu N, Richter C et al (2015) Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice

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According to the National Institutes of Health (NIH), no Tolerable Upper Intake Level (UL) has been established for B12, indicating that the risk of harm from high doses is low [*]