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Melatonin can activate antioxidant enzymes such as SOD, Catalase, and Glutathione peroxidase to boost the immune system or suppress the activity of pro-oxidant enzymes, such as xanthine oxidase

Stimulation of IR upregulates both mitogen-activated protein (MAP)/extracellular signal-regulated kinase and phosphoinositide 3-kinases/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways and subsequently leading to inhibiting of apoptosis and promoting cell migration and proliferation [33]

Article citation: Meda S, Singh SP, Palade PT, Tonk S, Awasthi S

And tissues would not get oxygen (suffer from Hypoxia)

Conversely, the Tri-weekly regimen focuses on convenience and potentially reduces adverse effects but may require a higher dose for effectiveness