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TGF- is a major fibrogenic cytokine, regulating the production, degradation and accumulation of the extracellular matrix in hepatic fibrosis

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It is important to note that there are currently some negative results of ASK1-related small molecule inhibitors (such as CFLAR-mimicking peptide) in clinical trials

To nominate therapeutic targets across subtypes, we developed a multiomic machine-learning approach and validated MTA1 as a contributor to panobinostat resistance

Skimping on sleep undermines IGF-1 LR3's potential effects