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Carcinogenesis
Meanwhile, the GH-IGF1 signaling involved in DNA damage response (DDR) and DNA damage repair determines the radio-resistance of cancer cells subjected to radiotherapy and repair of adjacent tissues damaged by radiotherapy
doi: 10.1016/j.jacc.2016.09.972 41 KalhanSCGuoLEdmisonJDasarathySMcCulloughAJHansonRWet al
In addition, several small molecules targeting lactate-generating or lactate-exporting proteins, including LDH inhibitors [321] and selective MCT1 blockers exemplified by AZD3965 [39], have advanced into early-phase clinical testing in lymphoma and solid tumors, where they aim to collapse lactate-fueled metabolic circuits and remodel the acidic TME
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